Discovery Projects - Grant ID: DP0773830

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0773830

Funding Status
Closed

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Funded Activity Summary

Theoretical and computational approaches to accurately predict the structures of a unique family of circular and knotted proteins. The primary outcome will be a fundamental new knowledge on cyclotide structures and a new protein engineering method to design stabilised proteins. Because cyclotides have significantly higher stabilities than conventional proteins, they have a range of pharmaceutical and agricultural applications. Both fields of use have the potential for very great economic and social benefits for Australia. From a pharmaceutical perspective our computing development will greatly facilitate the design of stabilised peptide-based drugs using the cyclotide framework. Such drugs have potential sales of several billion dollars per annum and the royalty returns from successful commercialisation of IP can be substantial.

Funded Activity Details

Start Date: 01-01-2007

End Date: 31-12-2010

Funding Scheme: Discovery Projects

Funding Amount: $266,090.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biotechnology | Macromolecular Design | Plant Protection (Pests, Diseases And Weeds) | Macromolecular and Materials Chemistry

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Crop and animal protection chemicals | Biological sciences |

Other Keywords

Biological sciences | Crop and animal protection chemicals | Macromolecular Design | Macromolecular and Materials Chemistry | Medical Biotechnology | Plant Protection (Pests, Diseases And Weeds) | Treatments (e.g. chemicals, antibiotics)

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