Discovery Projects - Grant ID: DP0771559

Funded Activity Summary

Proteolysis of binding protein complexes regulates bioavailability of insulin-like growth factor (IGF). We aim to determine how growth factors kept inactive in complexes in the blood can become free and active. The fundamental knowledge gained will help us understand the regulation of growth factors' availability to tissues and develop novel or more effective delivery systems for therapeutic growth factors that could impact on several conditions including diabetes, growth disorders and critical illness. This project therefore benefits Australia at two levels: by maintaining our international leadership in the study of these important growth-regulatory molecules, and by providing a better understanding of physiological mechanisms that might benefit the health of Australians and provide opportunities to develop novel therapeutics.

Funded Activity Details

Start Date: 01-02-2007

End Date: 31-01-2010

Funding Scheme: Discovery Projects

Funding Amount: $234,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biological Sciences Not Elsewhere Classified | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Endocrinology

ANZSRC Socio-Economic Objective (SEO)

Clinical health not specific to particular organs, diseases and conditions | Women’s health | Child health |

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological Sciences Not Elsewhere Classified | Child health | Clinical health not specific to particular organs, diseases and conditions | Endocrinology | Women’s health

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