Discovery Projects - Grant ID: DP0771404

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0771404

Funding Status
Closed

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Funded Activity Summary

The function of truncated MEK1 protein in a G2 phase cell cycle delay and in mitosis. Understanding cell proliferation. Intracellular signaling pathways controlling cell growth are often mutated in cancers and other hyperproliferative diseases. Understanding precisely how these pathways operate and how mutations of these pathways can contribute to uncontrolled growth can readily provide new targets for preventative therapies or cures. We have identified a novel mechanism regulating one component of a well studied pathway, the MAPK pathway, and new functions for this component. The contribution of this novel component to mechanisms involved in regulating cell growth previously through to be controlled by the canonical MAPK pathway could change our understanding of the fundamental mechanisms controlling cell growth.

Funded Activity Details

Start Date: 01-01-2007

End Date: 31-12-2009

Funding Scheme: Discovery Projects

Funding Amount: $263,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Cell Development (Incl. Cell Division And Apoptosis)

ANZSRC Socio-Economic Objective (SEO)

Cancer and related disorders | Biological sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Cancer and related disorders | Cell Development (Incl. Cell Division And Apoptosis) | Protein Targeting And Signal Transduction

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