Discovery Projects - Grant ID: DP0771155

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0771155

Funding Status
Closed

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Funded Activity Summary

Multivalent drug delivery carrier for the targeted delivery of platinum anticancer agents to hepatocytes. Hepatocellular carcinoma (HCC) is often treated with chemotherapy using cytotoxic drugs. This systemic treatment results in the distribution of the drug throughout the body. Employing a polymer particle as a drug carrier for these drugs ensures a temporal control of the release and therefore supply of the drug within the body. By attaching carbohydrate moieties onto the surface of the polymer particle the drug carrier can specifically be recognized by cell receptors, thus allowing a targeted delivery of the drug to the desired area in the body. A range of carbohydrate-based drug carriers will be synthesized and tested towards their interaction with hepatocytes to allow optimisation of this drug carrier system.

Funded Activity Details

Start Date: 01-01-2007

End Date: 31-12-2009

Funding Scheme: Discovery Projects

Funding Amount: $273,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Supramolecular Chemistry | Synthesis Of Macromolecules | Macromolecular and Materials Chemistry | Biomaterials |

ANZSRC Socio-Economic Objective (SEO)

Cancer and related disorders | Polymeric materials (e.g. paints)

Other Keywords

Biomaterials | Cancer and related disorders | Macromolecular and Materials Chemistry | Polymeric materials (e.g. paints) | Supramolecular Chemistry | Synthesis Of Macromolecules

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