Discovery Projects - Grant ID: DP0770888

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0770888

Funding Status
Closed

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Funded Activity Summary

Dissociation of a Tetrameric Enzyme with Interface-Targeted Peptides. With antibiotic resistance on the rise, there is an urgent need to develop new antibiotics and an equally urgent need to characterise new antibiotic targets. One such target is dihydrodipicolinate synthase (DHDPS) which catalyses the critical step in lysine and cell wall biosynthesis in bacteria. This proposal aims to generate new drugs targeting DHDPS for effective and rapid treatment of bacterial infections, including gastroenteritis. Recent statistics show that over 5 million Australians suffer from gastroenteritis each year and hospitalisation for this infection is nearly seven times higher for indigenous than non-indigenous children. Accordingly, this research has the potential to assure a healthier future for millions of Australians.

Funded Activity Details

Start Date: 01-01-2008

End Date: 31-12-2010

Funding Scheme: Discovery Projects

Funding Amount: $263,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Biological And Medical Chemistry | Bacteriology

ANZSRC Socio-Economic Objective (SEO)

Prevention—biologicals (e.g. vaccines) | Diagnostics | Treatments (e.g. chemicals, antibiotics) |

Other Keywords

Bacteriology | Biochemistry and Cell Biology | Biological And Medical Chemistry | Diagnostics | Enzymes | Prevention—biologicals (e.g. vaccines) | Treatments (e.g. chemicals, antibiotics)

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