Discovery Projects - Grant ID: DP0770839

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0770839

Funding Status
Closed

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Funded Activity Summary

Mannose metabolism in pathogenic microorganisms. Current treatments for tuberculosis and leishmaniasis are failing due to chronic underinvestment by the private sector and public agencies over many decades. The causative agents, the microorganisms Leishmania spp and Mycobacterium tuberculosis, respectively, use sugar processing pathways that differ from humans, and thus represent targets for new drugs. We will study two related sugar-processing biochemical pathways in these organisms. We will develop new ways to measure enzyme activity using mass spectrometry, and new reagents to clone several biosynthetic enzymes. Our work will lay a foundation for new antibiotics to combat these insidious diseases, and will foster Australian expertise in chemical biology and innovative basic science.

Funded Activity Details

Start Date: 01-01-2008

End Date: 31-12-2010

Funding Scheme: Discovery Projects

Funding Amount: $250,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medicinal and Biomolecular Chemistry | Biological And Medical Chemistry | Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

Infectious diseases | Treatments (e.g. chemicals, antibiotics) |

Other Keywords

Biological And Medical Chemistry | Cell Metabolism | Infectious diseases | Medicinal and Biomolecular Chemistry | Treatments (e.g. chemicals, antibiotics)

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