Discovery Projects - Grant ID: DP0770546

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0770546

Funding Status
Closed

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Funded Activity Summary

Autophagic vacuole formation in mammalian skeletal muscle; role of FOXO proteins. Loss of muscle tissue is a hallmark of many common health problems including cancer, HIV-Aids and renal failure. Recently, we identified that a family of transcription factors termed the forkhead box class-O (FOXO) winged helix transcription factors are key regulators of both anabolic (building) and catabolic (wasting) signalling pathways. This project will investigate the molecular regulation of cell integrity by FOXO proteins. Although very basic in nature, these projects will identify how FOXO proteins regulate muscle cell building and wasting and, therefore, present a potential therapeutic target for muscle wasting diseases, making this project highly significant.

Funded Activity Details

Start Date: 01-01-2007

End Date: 31-12-2009

Funding Scheme: Discovery Projects

Funding Amount: $285,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Cell Metabolism | Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Cancer and related disorders | Biological sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Cancer and related disorders | Cell Metabolism | Protein Targeting And Signal Transduction

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