Discovery Projects - Grant ID: DP0667150

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0667150

Funding Status
Closed

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Funded Activity Summary

A redox sensor and triple receptor function for guanylyl cyclase. Nitric oxide (NO) protects from blood vessel spasms and clot formation. Conversely, insufficient NO occurs in cardiovascular disease. Life-saving drugs like glycerol trinitrate supply more NO to blood vessels, however these drugs are limited in their action when their target protein (NOGC) is decreased or defective, eg. in hypertension or arteriosclerosis. We have elucidated the reason for this defect and simultaneously discovered an entirely novel group of drugs which activate NOGC without NO. Impressively, these drugs are most effective in diseased blood vessels. The aim is the development of novel blood pressure lowering/anti-anginal drugs with higher effectiveness and less side-effects because they work in an entirely new way.

Funded Activity Details

Start Date: 03-01-2006

End Date: 31-12-2008

Funding Scheme: Discovery Projects

Funding Amount: $298,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences | Basic Pharmacology | Cell Physiology | Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Health related to ageing | Cardiovascular system and diseases |

Other Keywords

Basic Pharmacology | Cardiovascular system and diseases | Cell Physiology | Health related to ageing | Nervous system and disorders | Pharmacology and Pharmaceutical Sciences | Protein Targeting And Signal Transduction

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