Discovery Projects - Grant ID: DP0666603

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0666603

Funding Status
Closed

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Funded Activity Summary

Elucidating the regulation of cell death by random mutagenesis of key apoptotic proteins. All organisms need to remove damaged or excessive cells. This cell death process is called apoptosis. Defects in apoptosis result in numerous diseases including cancer, and neurodegenerative and immune disorders. Determining how this process is regulated is of crucial importance for therapeutic intervention. We will utilise a powerful strategy to mutate proteins required for apoptosis so that they no longer work, which will allow the identification of protein regions essential for cell death activity . This will lead to identification of potential drug targets to control apoptosis. Elucidating the mechanism of cell death will lead to the development of novel and improved therapies for diseases such as cancer and neurodegenerative disease.

Funded Activity Details

Start Date: 01-01-2006

End Date: 31-12-2008

Funding Scheme: Discovery Projects

Funding Amount: $223,020.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Cell Development (Incl. Cell Division And Apoptosis)

ANZSRC Socio-Economic Objective (SEO)

Immune system and allergy | Nervous system and disorders | Cancer and related disorders |

Other Keywords

Biochemistry and Cell Biology | Cancer and related disorders | Cell Development (Incl. Cell Division And Apoptosis) | Immune system and allergy | Nervous system and disorders

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