Discovery Projects - Grant ID: DP0665546

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0665546

Funding Status
Closed

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Funded Activity Summary

Cystine flux and hydrogen peroxide breakdown in reuteri group lactobacilli. We have discovered, and aim to fully dissect a novel function of reuteri group lactobacilli. These microbes inhabit the surfaces of the gastrointestinal and reproductive tracts of humans and are also used as probiotics, and in the dairy industry. This function mediates the production and breakdown of large amounts of hydrogen peroxide, cystine and thiols. These are highly bioactive and affect human cells and other bacteria at the surfaces of the gastrointestinal and reproductive tracts, and thiols are also flavourants in dairy products. Our research will inform the rational development of probiotics, the management and treatment of unpleasant conditions such as Crohn's disease and bacterial vaginosis, and innovation in dairy fermentations.

Funded Activity Details

Start Date: 01-01-2006

End Date: 31-12-2009

Funding Scheme: Discovery Projects

Funding Amount: $267,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Microbial Genetics | Biochemistry and Cell Biology | Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

Digestive system and disorders | Dairy products | Biological sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Cell Metabolism | Dairy products | Digestive system and disorders | Microbial Genetics

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