Discovery Projects - Grant ID: DP0665422

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0665422

Funding Status
Closed

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Funded Activity Summary

Allosteric regulation, molecular structure and function of transglutaminase 2. With Australia's ageing population, we can expect to see increasing prevalence of pathologies such as cancer, Alzheimer's disease, and cataracts. The ubiquitous enzyme transglutaminase 2 (TG2) has been implicated in all of these age-related diseases, as well as in chronic disorders such as coeliac disease and diabetes, and may contribute in a positive way to wound healing. Understanding how TG2 is activated and inactivated, and how it selects its targets, will be a critical addition to current knowledge of this enzyme, and will be an essential prerequisite for the development of TG2-targetted drugs and other TG2-related therapies.

Funded Activity Details

Start Date: 01-01-2006

End Date: 30-06-2009

Funding Scheme: Discovery Projects

Funding Amount: $190,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Structural Chemistry | Physical Chemistry (Incl. Structural) | Mechanisms Of Reactions

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Biological sciences |

Other Keywords

Biological sciences | Enzymes | Mechanisms Of Reactions | Physical Chemistry (Incl. Structural) | Structural Chemistry | Treatments (e.g. chemicals, antibiotics)

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