Discovery Projects - Grant ID: DP0664192

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0664192

Funding Status
Closed

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Funded Activity Summary

Characterisation of a novel neural-specific ATPase in cholesterol transport. Ageing is determined by both genetic and metabolic factors. To a large part, the detailed mechanisms of ageing remain to be unexplored. Genetically, the timing of cell ageing entails the loss of telomeres (tips of chromosomes). However, the buildup of metabolic wastes resets the timing prematurely. Metabolic products accumulate from excess production or a shortfall of removal activity, which occurs in the various parts of ageing cells in tissues such as brain. Traffic jams of cholesterol transport in the secretory pathway induce early ageing of the nerve cells. We investigate a novel mechanism controlling cholesterol transport in nerve cell ageing.

Funded Activity Details

Start Date: 01-01-2006

End Date: 31-12-2008

Funding Scheme: Discovery Projects

Funding Amount: $256,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Membrane Biology | Cell Neurochemistry

ANZSRC Socio-Economic Objective (SEO)

Mental health | Nervous system and disorders | Health related to ageing |

Other Keywords

Biochemistry and Cell Biology | Cell Neurochemistry | Health related to ageing | Membrane Biology | Mental health | Nervous system and disorders | Protein Targeting And Signal Transduction

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