Discovery Projects - Grant ID: DP0664184

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0664184

Funding Status
Closed

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Funded Activity Summary

Fluorine-labelled proteins for NMR spectroscopy. The technique developed in this project has direct impact on pharmaceutical research: NMR spectroscopy is used routinely to identify chemical compounds that bind to protein targets. This project includes the development of novel assignment techniques of 19F-labelled proteins, so that 19F-NMR can be used to detect specific binding interactions. One of the methods proposed here is designed to reveal structural information about the binding mode in solution with atomic detail. This knowledge can significantly accelerate drug development. It is otherwise only available from crystal structures that can not always be determined.

Funded Activity Details

Start Date: 01-01-2006

End Date: 31-12-2008

Funding Scheme: Discovery Projects

Funding Amount: $388,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Analytical Biochemistry | Organic Chemical Synthesis | Optimisation |

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Other

Other Keywords

Analytical Biochemistry | Biochemistry and Cell Biology | Biological sciences | Optimisation | Organic Chemical Synthesis | Other

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