Discovery Projects - Grant ID: DP0664039

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0664039

Funding Status
Closed

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Funded Activity Summary

Directed evolution of enzymes for bioremediation: structure function studies of bimetalloenzymes. We will evolve enzymes that degrade organophosphate pesticides (OPs) that are used in Australian agriculture. Although these OPs were designed to kill insects they are closely related to chemical warfare agents and are known to be toxic to humans. Bacteria have acquired a number of enzymes that degrade some OPs. One such enzyme has been used in field trials demonstrating its potential to degrade OP residues. However, many pesticides are not removed rapidly and OP-degrading enzymes require modification(s) if they are to be useful environmental reagents - this can be achieved with directed evolution.

Funded Activity Details

Start Date: 01-01-2006

End Date: 30-06-2009

Funding Scheme: Discovery Projects

Funding Amount: $256,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetic Engineering And Enzyme Technology | Bioinorganic Chemistry | Biochemistry And Cell Biology Not Elsewhere Classified | Inorganic Chemistry

ANZSRC Socio-Economic Objective (SEO)

Land and water management | Agricultural chemicals | Biological sciences |

Other Keywords

Agricultural chemicals | Biochemistry And Cell Biology Not Elsewhere Classified | Bioinorganic Chemistry | Biological sciences | Genetic Engineering And Enzyme Technology | Inorganic Chemistry | Land and water management

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