Discovery Projects - Grant ID: DP0663967

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0663967

Funding Status
Closed

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Funded Activity Summary

Mechanisms and consequences of oxidation of glycosaminoglycans, proteins and proteoglycans by myeloperoxidase-derived oxidants. Atherosclerosis (hardening of the arteries) is responsible for the death of 40% of the population of developed, and developing, countries including Australia. Rupture of the fibrous cap of atherosclerotic lesions is responsible for most sudden deaths from heart disease and stokes, but is a poorly understood process. Evidence has been presented for a role for oxidation reactions in weakening the structure of lesions and making them prone to rupture. Little is known about the fundamental chemistry of such damage; this will be addressed in the proposed program. The data obtained will underpin the development of new preventative and protective strategies to minimise lesion rupture and deaths from this major disease.

Funded Activity Details

Start Date: 23-06-2006

End Date: 24-09-2008

Funding Scheme: Discovery Projects

Funding Amount: $352,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Biological And Medical Chemistry | Analytical Biochemistry | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular system and diseases | Biological sciences | Chemical sciences |

Other Keywords

Analytical Biochemistry | Biochemistry and Cell Biology | Biological And Medical Chemistry | Biological sciences | Cardiovascular system and diseases | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall) | Chemical sciences

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