Discovery Projects - Grant ID: DP0663862

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0663862

Funding Status
Closed

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Funded Activity Summary

Reducing the fat burden: Identification of novel cellular and molecular targets for alleviating skeletal muscle insulin resistance. Insulin resistance and the associated consequences are a major public health problem in Australia and cost the healthcare system >$1.1 billion/year. Exercise training and thiaziolidinedione (TZD) treatment are therapies that partially ameliorate insulin resistance through distinct and independent mechanisms. However, neither intervention represents a viable long-term strategy: exercise training has low compliance, while chronic TZD use is associated with several adverse side effects (edema, weight gain etc.). We will investigate the metabolic, cellular and molecular mechanisms by which these therapies each exert their positive effect on insulin action with the aim of identifying novel targets for future drug interventions.

Funded Activity Details

Start Date: 01-01-2006

End Date: 31-12-2009

Funding Scheme: Discovery Projects

Funding Amount: $200,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Medical Biochemistry: Lipids | Cell Metabolism | Exercise Physiology

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Cell Metabolism | Exercise Physiology | Medical Biochemistry: Lipids

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