Discovery Projects - Grant ID: DP0663818

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0663818

Funding Status
Closed

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Funded Activity Summary

Involvement of cell coupling in vascular function: Development of a computational model. Gap junctions are intercellular channels which enable the production of coordinated responses in multicellular tissues and organs. Blood vessels are comprised of endothelial cells surrounded by smooth muscle cells and gap junctions exist within and between these layers. The present proposal will determine the fundamental role of gap junctions in regulating blood flow and blood pressure. Our data will enable us to develop a computational model of the vascular wall and so predict how changes in electrical properties, as occur during pressure changes, can influence blood flow. Since ageing is accompanied by an increase in blood pressure, our results will contribute to a better understanding of blood flow regulation in our ageing population.

Funded Activity Details

Start Date: 15-03-2006

End Date: 31-08-2009

Funding Scheme: Discovery Projects

Funding Amount: $275,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Animal Physiology—Systems | Physiology | Animal Physiology—Biophysics | Biological Mathematics

ANZSRC Socio-Economic Objective (SEO)

Health related to ageing | Biological sciences |

Other Keywords

Animal Physiology—Biophysics | Animal Physiology—Systems | Biological Mathematics | Biological sciences | Health related to ageing | Physiology

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