Discovery Projects - Grant ID: DP0559560

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0559560

Funding Status
Closed

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Funded Activity Summary

Mechanistic studies on the oxidation of amino acids, peptides and proteins and its biological consequences. Exposure of amino acids and proteins to radicals, oxidants, UV light, and metal ions results in oxidation, with consequent alteration to protein structure and function. It has been shown that these reactions occur during food spoilage, exposure of plants to excess UV light, and in a number of human diseases (e.g. heart disease and cancer). Despite evidence for a key role for protein oxidation in these events, the fundamental chemistry and biochemistry of protein oxidation is incompletely understood. This is addressed in this project. Knowledge of the mechanisms of these reactions is a vital pre-requisite to the rational design of preventative strategies that might enhance food quality, minimise UV damage and enhance human health.

Funded Activity Details

Start Date: 14-01-2005

End Date: 31-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $390,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Biological And Medical Chemistry | Analytical Biochemistry |

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Chemical sciences

Other Keywords

Analytical Biochemistry | Biochemistry and Cell Biology | Biological And Medical Chemistry | Biological sciences | Chemical sciences | Enzymes

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