Discovery Projects - Grant ID: DP0558537

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0558537

Funding Status
Closed

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Funded Activity Summary

Gene Discovery and Functional Analysis of Copper Homeostasis Genes in Drosophila. Copper is a vital nutrient required for the formation and maintenance of bones, blood vessels and the central nervous system, but copper is also potentially toxic when in excess. Homeostatic mechanisms are needed to maintain safe levels of copper in the body and disruptions to these mechanisms are associated with disorders such as Alzheimer's disease, heart disease and osteoporosis. We are investigating the regulation of a key copper pump, the Menkes protein, which helps control copper levels in the body and we are using the genetic advantages of the fruit fly Drosophila to discover new genes that regulate Menkes activity and therefore copper levels. These studies could lead to novel therapies for a range of copper-related disorders.

Funded Activity Details

Start Date: 01-01-2005

End Date: 31-12-2008

Funding Scheme: Discovery Projects

Funding Amount: $320,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Cell Metabolism | Protein Targeting And Signal Transduction | Genetic Development (Incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Nutrition | Inherited diseases (incl. gene therapy) |

Other Keywords

Biochemistry and Cell Biology | Cell Metabolism | Genetic Development (Incl. Sex Determination) | Inherited diseases (incl. gene therapy) | Nervous system and disorders | Nutrition | Protein Targeting And Signal Transduction

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