Discovery Projects - Grant ID: DP0558374

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0558374

Funding Status
Closed

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Funded Activity Summary

BIOSYNTHESIS OF A FUNGAL TOXIN AND ITS ROLE IN PLANT DISEASE. This project will determine how an important class of toxic molecules, epipolythiodioxopiperazines (EPTs), are made by fungi. Knowledge of the domains and actions of these genes in the biosynthetic pathway may lead to the ability to engineer secondary metabolites with altered specificity, and drugs that alleviate symptoms of secondary fungal toxicoses associated with leukemia, organ transplants and HIV AIDS. Also this project will also elucidate the role of an EPT, sirodesmin, in blackleg of canola, a disease that costs the Australian canola industry up to $50 million in losses annually. Outcomes of this project may lead to novel blackleg disease control strategies.

Funded Activity Details

Start Date: 01-01-2005

End Date: 31-12-2008

Funding Scheme: Discovery Projects

Funding Amount: $230,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Plant Pathology | Physical Chemistry (Incl. Structural) | Mechanisms Of Reactions | Mycology

ANZSRC Socio-Economic Objective (SEO)

Immune system and allergy | Oilseeds | Cancer and related disorders |

Other Keywords

Cancer and related disorders | Immune system and allergy | Mechanisms Of Reactions | Mycology | Oilseeds | Physical Chemistry (Incl. Structural) | Plant Pathology

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