Discovery Projects - Grant ID: DP0453391

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0453391

Funding Status
Closed

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Funded Activity Summary

Exploration of a mechanistic link between eukaryotic transcription and translation. Gene transcription is functionally coupled to other aspects of eukaryotic mRNA metabolism, emphasizing a need for integrated approaches to analyse the gene expression pathway. We have shown in previous work that yeast cells, when responding to external stimuli, show a tight correlation between changes in the transcriptome composition and homodirectional alterations in the translation state of mRNAs. This phenomenon of ?potentiation? may serve to amplify signal-induced changes in the transcriptome at the translational level. This project will begin to unravel the molecular mechanisms underlying potentiation using experiments designed to distinguish between transcription- and translation-driven mechanisms.

Funded Activity Details

Start Date: 01-01-2004

End Date: 31-12-2006

Funding Scheme: Discovery Projects

Funding Amount: $240,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Microbial Genetics | Gene Expression | Protein Targeting And Signal Transduction | Genetics

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Organs, diseases and abnormal conditions not elsewhere classified |

Other Keywords

Biological sciences | Gene Expression | Genetics | Microbial Genetics | Organs, diseases and abnormal conditions not elsewhere classified | Protein Targeting And Signal Transduction

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