Discovery Projects - Grant ID: DP0452026

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0452026

Funding Status
Closed

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Funded Activity Summary

Role of a novel zinc-binding motif in the structure-function of deubiquitinating enzymes. The ubiquitin pathway destroys many proteins that control cell function and growth, by attaching ubiquitin to them and marking them for degradation. Deubiquitinating enzymes (DUBs) regulate protein destruction by controlling the amount of ubiquitin attached. DUBs and the ubiquitin pathway can also be manipulated in biotechnology applications. However, very little is known about the structure/function of DUBs. We have identified a new zinc-binding motif in DUBs, and we will explore how this contributes to their structure, and interactions with other proteins. This will significantly enhance our knowledge of how DUBs function in both biotechnology and in controlling cell function.

Funded Activity Details

Start Date: 01-01-2004

End Date: 31-12-2007

Funding Scheme: Discovery Projects

Funding Amount: $225,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Genetic Engineering And Enzyme Technology | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Cell Metabolism | Genetic Engineering And Enzyme Technology

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