Discovery Projects - Grant ID: DP0451515

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0451515

Funding Status
Closed

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Funded Activity Summary

Synthesis of the pyrrolo[2,1-c][1,4]benzodiazepines: potent DNA binders. Chemicals that bind to DNA have a long history of use as anticancer drugs. In recent times, the biotechnology revolution has greatly expanded our understanding of how these drugs work and the genetic basis of a wide range of other diseases. The aim of this project is to discover novel compounds that selectively bind to DNA. Starting from a class of naturally occurring compounds (called the pyrrolobenzodiazepines) as a template, it will develop powerful new methods to supply wholly new DNA interactive molecules with great potential as new drugs to treat cancer or other genetic diseases.

Funded Activity Details

Start Date: 01-03-2004

End Date: 31-12-2007

Funding Scheme: Discovery Projects

Funding Amount: $330,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Organic Chemistry | Biological And Medical Chemistry | Organic Chemical Synthesis |

ANZSRC Socio-Economic Objective (SEO)

Treatments (e.g. chemicals, antibiotics) | Cancer and related disorders | Chemical sciences

Other Keywords

Biological And Medical Chemistry | Cancer and related disorders | Chemical sciences | Organic Chemical Synthesis | Organic Chemistry | Treatments (e.g. chemicals, antibiotics)

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