Discovery Projects - Grant ID: DP0451202

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0451202

Funding Status
Closed

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Funded Activity Summary

Hierarchical modeling of protein interactions. Protein interactions play a central role in function and structural organization of cells. Their elucidation is essential for a better understanding of many cellular processes from signal transduction to enzyme inhibition. The aim of this project is to utilize the unprecedented powers of current supercomputers in developing a hierarchical model of protein interactions. The method combines Brownian dynamics at large distances and long time scales with molecular dynamics at small distances and shorter times. Applications to both membrane proteins (blocking of ion channels by toxins and drugs) and globular proteins (ligand binding to receptors and protein association) will be considered.

Funded Activity Details

Start Date: 01-04-2004

End Date: 01-04-2007

Funding Scheme: Discovery Projects

Funding Amount: $186,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Membrane Biology | Biophysics

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Biological sciences | Physical sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Biophysics | Membrane Biology | Nervous system and disorders | Physical sciences | Protein Targeting And Signal Transduction

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