Discovery Projects - Grant ID: DP0450859

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0450859

Funding Status
Closed

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Funded Activity Summary

Progenitor cells within the peritoneal cavity. Implantation of a foreign object into the peritoneal cavity of animals recruits undifferentiated cells of bone marrow origin that encapsulate the free-floating object, then differentiate into myofibroblasts. When large pieces of myofibroblast capsule tissue are subsequently grafted into autologous artery, bladder or vas deferens, they develop the structure and morphology of that organ. We hypothesise that multipotent progenitor cells sequestered to the peritoneal cavity can be manipulated to differentiate along smooth muscle and other pathways. The proposed project aims to identify the origin of these cells and characterise the transcriptional program that regulates their differentiation.

Funded Activity Details

Start Date: 01-01-2004

End Date: 31-12-2006

Funding Scheme: Discovery Projects

Funding Amount: $240,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Gene Expression | Cell Development (Incl. Cell Division And Apoptosis) | Biotechnology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Organs, diseases and abnormal conditions not elsewhere classified |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Biotechnology Not Elsewhere Classified | Cell Development (Incl. Cell Division And Apoptosis) | Gene Expression | Organs, diseases and abnormal conditions not elsewhere classified

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