Discovery Projects - Grant ID: DP0450808

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0450808

Funding Status
Closed

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Funded Activity Summary

NMR studies of membrane proteins and peptides in novel amphiphilic mesophases. Membrane proteins are the next frontier in structural biology. Our goal is the structural and mechanistic characterization of the proteins and peptides from platypus venom and a cardiac potassium ion channel, HERG, that has a particular role in the suppression of cardiac arrhythmias. To do this we will refine and develop methods using amphiphilic mesophases and micelles and state-of-the-art NMR spectroscopy. Electrophysiological analysis of ion channels and interactions with toxins will relate NMR structures to function. The NMR methodologies we develop will have broad applicability to membrane proteins in general.

Funded Activity Details

Start Date: 01-02-2004

End Date: 30-01-2009

Funding Scheme: Discovery Projects

Funding Amount: $1,250,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Other Physical Sciences | Membrane Biology | Instruments And Techniques | Biophysics

ANZSRC Socio-Economic Objective (SEO)

Biological sciences | Chemical sciences | Physical sciences |

Other Keywords

Biological sciences | Biophysics | Chemical sciences | Instruments And Techniques | Membrane Biology | Other Physical Sciences | Physical sciences

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