Discovery Projects - Grant ID: DP0450213

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0450213

Funding Status
Closed

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Funded Activity Summary

The effect of nitrogen monoxide on intracellular iron metabolism. During our current ARC grant we discovered a novel relationship between energy metabolism and NO-mediated Fe efflux and showed that glutathione (GSH) is vital for this release mechanism (DR5,6). Intriguingly, this transport process is part of the cytotoxic effector machinery of activated macrophages against tumours, and requires further elucidation. We also showed that CO affects Fe metabolism by binding to Fe, and CO may modulate NO's function. We will:- (1) Examine if NO-mediated Fe release results in GSH efflux (2) Identify the mechanism of NO-mediated Fe efflux. (3) Assess the effect of inducing haem oxygenase 1 on Fe metabolism

Funded Activity Details

Start Date: 15-04-2004

End Date: 30-06-2007

Funding Scheme: Discovery Projects

Funding Amount: $255,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Cell Metabolism

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