Discovery Projects - Grant ID: DP0450051

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0450051

Funding Status
Closed

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Funded Activity Summary

AAA+ proteases: substrate binding, translocation and modulation by novel adaptor proteins. Protein quality control is essential for the proper maintenance of the cell. It ensures the correct folding of newly synthesised proteins, the refolding or degradation of misfolded and aggregated proteins, and the controlled degradation of regulatory proteins. These functions are collectively performed by molecular chaperones and proteases. This project will define the molecular basis of substrate selectivity for ATP-dependent proteases and determine the relationship between chaperones and proteases. A major focus will be directed towards the mechanistic analysis of novel AAA+ cofactors such as ClpS, which we recently discovered. A detailed analysis of such proteins is central to understanding how chaperones and protease (a) recognize their substrates and (b) compete for different substrates in vivo.

Funded Activity Details

Start Date: 01-05-2004

End Date: 01-09-2009

Funding Scheme: Discovery Projects

Funding Amount: $1,100,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Analytical Biochemistry | Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

Other Keywords

Analytical Biochemistry | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological sciences | Protein Targeting And Signal Transduction

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