Discovery Projects - Grant ID: DP0450001

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0450001

Funding Status
Closed

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Funded Activity Summary

Chemical and Biochemical Characterisation of Novel Iron Chelators with Therapeutic Potential. Iron is essential for life, but iron-overload is a potentially fatal condition. There is no natural mechanism to excrete iron in humans, so patients suffering from iron-overload disorders are treated with the chelator Desferal to enable iron excretion typically from an early age. Desferal is orally ineffective and must be given by subcutaneous infusion (12-24h, 5-6 days/week) resulting in poor patient compliance. We will conduct critical chemical and biological experiments with a new series of potentially orally active iron chelators identified in our lab. The results from this project will be vital for the development of these compounds as pharmaceuticals.

Funded Activity Details

Start Date: 01-01-2004

End Date: 31-12-2007

Funding Scheme: Discovery Projects

Funding Amount: $280,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Bioinorganic Chemistry | Cell Metabolism | Inorganic Chemistry

ANZSRC Socio-Economic Objective (SEO)

Preventive medicine | Treatments (e.g. chemicals, antibiotics) |

Other Keywords

Bioinorganic Chemistry | Cell Metabolism | Inorganic Chemistry | Preventive medicine | Treatments (e.g. chemicals, antibiotics)

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