Discovery Projects - Grant ID: DP0449904

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0449904

Funding Status
Closed

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Funded Activity Summary

Realistic models of permeation in ion channels. Ion channels are formed by proteins in cell membranes and provide pathways for fast and controlled flow of selected ions. This activity generates action potentials in nerves and muscles that forms the basis of all movement, sensation and thought processes. Recent determination of the crystal structure of channel proteins has enabled construction of models that can relate channel function to its structure--necessary for understanding their operation and seeking cures for diseases caused by their malfunction. This project aims to develop accurate ion-protein-water interactions for permeation models based on stochastic and molecular dynamics simulations using both classical and quantum mechanical methods.

Funded Activity Details

Start Date: 01-02-2004

End Date: 03-01-2008

Funding Scheme: Discovery Projects

Funding Amount: $210,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Other Physical Sciences | Membrane Biology | Biophysics | Quantum Chemistry

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Biological sciences | Physical sciences |

Other Keywords

Biological sciences | Biophysics | Membrane Biology | Nervous system and disorders | Other Physical Sciences | Physical sciences | Quantum Chemistry

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