Discovery Projects - Grant ID: DP0449708

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0449708

Funding Status
Closed

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Funded Activity Summary

Investigation of a Phagocytic Synapse in the Uptake of Apoptotic Cells. Rapid clearance of cells that die by apoptosis is crucial for embryonic development, tissue turnover, and after inflammatory events. Specialised phagocytes engulf the apoptotic cell corpses in a way that minimises inflammation and prevents autoimmunity. Genetic studies have identified the key evolutionary receptors involved, but the molecular basis of this phagocytosis is still poorly understood. We have developed, and seek to establish, an integrated model that incorporates new findings to explain how the distinctive functions of specialised receptors can be orchestrated to achieve this function. A successful outcome to the project will provide new knowledge of value to human health.

Funded Activity Details

Start Date: 01-01-2004

End Date: 30-06-2007

Funding Scheme: Discovery Projects

Funding Amount: $660,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Membrane Biology | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

Immune system and allergy |

Other Keywords

Biochemistry and Cell Biology | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall) | Immune system and allergy | Membrane Biology | Protein Targeting And Signal Transduction

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