Discovery Projects - Grant ID: DP0449693

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0449693

Funding Status
Closed

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Funded Activity Summary

Proteomic analysis of subcellular changes during apoptosis. This project aims to use a novel proteomic approach to examine mechanisms of apoptosis at the level of the plasma membrane, mitochondrion, nucleus and cytosol, screening protein extracts of cell organelles by the new technique of SELDI-TOF mass spectrometry in which proteins are adsorbed onto activated chips. This will provide protein mass profiles characteristic of various stages of apoptosis, and will allow identification of proteins of interest by conventional proteomic methods. The establishment of SELDI-MS as a viable tool for cell proteomics would open new opportunities to understand a broad range of cellular functions at the level of protein expression.

Funded Activity Details

Start Date: 27-01-2004

End Date: 31-12-2006

Funding Scheme: Discovery Projects

Funding Amount: $270,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Membrane Biology | Cell Development (Incl. Cell Division And Apoptosis) | Biotechnology Not Elsewhere Classified

ANZSRC Socio-Economic Objective (SEO)

Clinical health not specific to particular organs, diseases and conditions | Cancer and related disorders | Biological sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Biotechnology Not Elsewhere Classified | Cancer and related disorders | Cell Development (Incl. Cell Division And Apoptosis) | Clinical health not specific to particular organs, diseases and conditions | Membrane Biology

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