Discovery Projects - Grant ID: DP0449683

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0449683

Funding Status
Closed

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Funded Activity Summary

Role of 3'-phosphorylated phosphoinositides in neurosecretion. Neurons communicate through the release of neurotransmitter by synaptic vesicles. Minute changes underlie normal processes such as memory and modifications of neurotransmitter level contribute to a number of neurological diseases. I am interested in deciphering the role of phosphoinositides, an inner membrane-based lipid, during steps leading to the fusion of a synaptic vesicle with the plasma membrane. I have recently discovered that phosphatidylinositol-3 phosphate production was critical for the vesicle to acquire the competence to fuse with the plasma membrane. This project aim to understand by which mechanism this lipid interacts with the release machinery to promote such priming step.

Funded Activity Details

Start Date: 01-01-2004

End Date: 31-12-2007

Funding Scheme: Discovery Projects

Funding Amount: $240,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

Mental health | Nervous system and disorders | Endocrine organs and diseases (incl. diabetes) |

Other Keywords

Biochemistry and Cell Biology | Endocrine organs and diseases (incl. diabetes) | Enzymes | Membrane Biology | Mental health | Nervous system and disorders | Protein Targeting And Signal Transduction

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