Discovery Projects - Grant ID: DP0449625

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0449625

Funding Status
Closed

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Funded Activity Summary

Understanding and exploiting bacterial sulfatases. Bacterial sulfatases participate in environmental nutrient cycling and are implicated in bacterial pathogenesis mechanisms. These enzymes catalyze the hydrolysis of sulfate esters and possess an unusual posttranslational active-site modification where a cysteine residue is oxidized to formylglycine. We will study the mechanism of these enzymes in detail and design inhibitors that exploit the reactivity of this aminoacid. This work has significance because of application to areas that include the treatment of cancer and bacterial infections. Additionally, we will clone novel carbohydrate sulfatases from the heparin-degrading bacterium Flavobacterium heparinum. These sulfatases will have use in biotechnology for characterization of sulfated glycoconjugates.

Funded Activity Details

Start Date: 11-12-2003

End Date: 31-12-2007

Funding Scheme: Discovery Projects

Funding Amount: $390,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Medicinal and Biomolecular Chemistry | Biological And Medical Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Medical instrumentation | Inherited diseases (incl. gene therapy) | Control of pests and exotic species

Other Keywords

Biological And Medical Chemistry | Control of pests and exotic species | Enzymes | Inherited diseases (incl. gene therapy) | Medical instrumentation | Medicinal and Biomolecular Chemistry

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