Discovery Projects - Grant ID: DP0449598

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0449598

Funding Status
Closed

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Funded Activity Summary

Searching for genes influencing reading ability using multivariate genomic linkage analysis and allelic association analysis. Following from the replicated linkages of reading disability to loci on chromosomes 6 & 18, this study examines linkage of these same regions to a range of reading measures in an unselected sample of twins and siblings. Preliminary univariate linkage scans of two neuropsychological reading indices suggest linkage to loci on two chromosomes. Our next step is to include reading measures of orthographic skill and phonological decoding in a multivariate linkage analysis with the other reading indices and with measures of IQ and academic achievement. Multivariate linkage increases the power of detecting quantitative traits and assists in defining the phenotype related to the locus. We then aim to identify the functional gene through allelic association analysis. Identification of QTLs for reading ability may lead to practical outcomes such as the behavioural and biomedical management of reading deficits, which may then benefit areas such as scholastic achievement.

Funded Activity Details

Start Date: 01-01-2004

End Date: 31-12-2006

Funding Scheme: Discovery Projects

Funding Amount: $225,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Quantitative Genetics | Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) | Genetics

ANZSRC Socio-Economic Objective (SEO)

Education and training not elsewhere classified | Behavioural and cognitive sciences |

Other Keywords

Behavioural and cognitive sciences | Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology) | Education and training not elsewhere classified | Genetics | Quantitative Genetics

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