Discovery Projects - Grant ID: DP0449575

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0449575

Funding Status
Closed

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Funded Activity Summary

Resurgent Sodium Currents in Peripheral Nerve Axons and Sensory Neurones. This project seeks evidence that unusual gating of sodium channels contributes to the hyperexcitability that results in spontaneous impulse activity in sensory axons. It asks whether axons normally behave as if they have this gating mode, whether it can be induced, whether any such behaviour is more prominent with sensory axons than motor, and whether the current can be measured directly in sensory neurones. The project is the first to involve correlation of patch-clamp recordings with the behaviour of intact axons. Its outcomes will affect thought about sodium channel behaviour and may alter approaches to disorders of axonal excitability.

Funded Activity Details

Start Date: 09-03-2004

End Date: 03-12-2007

Funding Scheme: Discovery Projects

Funding Amount: $270,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Physiology | Membrane Biology | Neurobiology | Animal Physiology—Biophysics

ANZSRC Socio-Economic Objective (SEO)

Behavioural and cognitive sciences | Biological sciences |

Other Keywords

Animal Physiology—Biophysics | Behavioural and cognitive sciences | Biological sciences | Membrane Biology | Neurobiology | Physiology

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