Discovery Projects - Grant ID: DP0449510

Funded Activity Summary

Protein-protein interactions in amyloid deposits. The aggregation of specific proteins to form insoluble amyloid fibrils is characteristic of several age-related diseases such as type-II diabetes, Alzheimer's disease and Parkinson's disease. In vivo amyloid deposits also contain three prominent non-fibrillar protein components, namely serum amyloid P component, apolipoprotein E and alpha1-antichymotrypsin. These non-fibrillar amyloid components bind to a wide variety of amyloid fibrils, irrespective of the nature of the protein constituent. This proposal is to identify the structural basis for this recognition process, the capacity of non-fibrillar components to cross-link amyloid fibrils to form networks and the influence of these interactions on amyloid fibril cytotoxicity.

Funded Activity Details

Start Date: 11-12-2003

End Date: 31-12-2007

Funding Scheme: Discovery Projects

Funding Amount: $360,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Biochemistry: Proteins And Peptides | Macromolecular and Materials Chemistry | Characterisation Of Macromolecules | Physical Chemistry Of Macromolecules

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular system and diseases | Biological sciences | Organs, diseases and abnormal conditions not elsewhere classified |

Other Keywords

Biological sciences | Cardiovascular system and diseases | Characterisation Of Macromolecules | Macromolecular and Materials Chemistry | Medical Biochemistry: Proteins And Peptides | Organs, diseases and abnormal conditions not elsewhere classified | Physical Chemistry Of Macromolecules

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