Discovery Projects - Grant ID: DP0346729

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0346729

Funding Status
Closed

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Funded Activity Summary

microRNAs: discovery and analysis in mouse development. MicroRNAs (miRNAs) are a new class of regulatory molecule, recently found to be abundant and strongly conserved in several eukaryotic species, encoded by genes that are transcribed into short stem-loop structures and then processed into ~22nt single-stranded RNAs by the RNAi pathway. We have cloned novel miRNAs, and obtained the first evidence for regulation of a miRNA in a mammal. We propose to continue cloning novel miRNAs by the tried method, and to explore bioinformatics-based methods of identification. We will also study the expression of miRNAs in mouse embryos at successive stages, and develop a microarray assay for miRNA expression.

Funded Activity Details

Start Date: 01-01-2003

End Date: 01-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $240,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression | Genome Structure | Genetics | Genetic Development (Incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

Organs, diseases and abnormal conditions not elsewhere classified |

Other Keywords

Gene Expression | Genetic Development (Incl. Sex Determination) | Genetics | Genome Structure | Organs, diseases and abnormal conditions not elsewhere classified

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