Discovery Projects - Grant ID: DP0346724

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0346724

Funding Status
Closed

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Funded Activity Summary

Co-ordinated Action of ATM and DNA-PK in DNA damage recognition. The aim of this project is to investigate the mechanism of repair of double straind breaks in DNA sustained after radiation damage. Specifically we will focus on two proteins ATM (mutated in the genetic disorder ataxia-telangiectasia) and DNA-PK mutated in scid mice. There two proteins recognize double straind breaks in DNA and signal this damage to the DNA repair machinery of the cell and to cell cycle checkpoints. The emphasis here will be in the relationship between the two proteins in co-ordinating the repair of breaks in DNA. This information will be important in understanding mechanisms for maintaining the integrity of the genome.

Funded Activity Details

Start Date: 01-01-2003

End Date: 31-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $225,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene Expression | Protein Targeting And Signal Transduction | Genome Structure | Genetics

ANZSRC Socio-Economic Objective (SEO)

Cancer and related disorders | Biological sciences | Inherited diseases (incl. gene therapy) |

Other Keywords

Biological sciences | Cancer and related disorders | Gene Expression | Genetics | Genome Structure | Inherited diseases (incl. gene therapy) | Protein Targeting And Signal Transduction

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