Discovery Projects - Grant ID: DP0346661

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0346661

Funding Status
Closed

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Funded Activity Summary

Conantokin selectivity for heteromeric N-methyl-D-aspartate (NMDA) receptors. NMDA receptors are ligand gated ion channels formed by heterogeneous population of subunits with distinct pharmacological and biophysical properties. The heterogeneic receptors are differentially expressed during development and play an important role in many physiological and pathological processes. Conantokins are toxins isolated from Conus venoms, which target NMDA receptor subunits with high affinity. The primary goal of this study is to examine the effects of conantokins on the molecular properties of different NMDA receptor subtypes in vivo and in vitro.

Funded Activity Details

Start Date: 01-01-2003

End Date: 31-12-2006

Funding Scheme: Discovery Projects

Funding Amount: $265,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Biochemistry and Cell Biology | Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Treatments (e.g. chemicals, antibiotics) | Biological sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Cellular Nervous System | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Membrane Biology | Nervous system and disorders | Treatments (e.g. chemicals, antibiotics)

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