Discovery Projects - Grant ID: DP0346325

Funding Activity

Website
https://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0346325

Funding Status
Closed

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Funded Activity Summary

Novel insecticidal neurotoxins from Australian spider venoms. Insecticidal toxins have considerable potential as novel biopesticides to combat the evolution of widespread insect resistance to classical chemical pesticides. This problem is increasing both in Australia and internationally. This study aims to isolate and pharmacologically characterise potent and selective insecticidal neurotoxins from Australian arachnids. Our laboratories will isolate neurotoxins from spider venoms, determine their selectivity in insect and mammal bioassays, determine their primary and tertiary structures, and investigate their structure-function relationships by electrophysiological techniques. These functional and structural data will allow the future engineering, by molecular or synthetic procedures, of viral biopesticide analogues with increased potency, stability and selectivity.

Funded Activity Details

Start Date: 23-01-2003

End Date: 31-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $135,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Pharmacology and Pharmaceutical Sciences | Neurosciences Not Elsewhere Classified | Pharmacology Not Elsewhere Classified | Protein Targeting And Signal Transduction |

ANZSRC Socio-Economic Objective (SEO)

Health and support services not elsewhere classified | Biological sciences | Field crops not elsewhere classified

Other Keywords

Biological sciences | Field crops not elsewhere classified | Health and support services not elsewhere classified | Neurosciences Not Elsewhere Classified | Pharmacology Not Elsewhere Classified | Pharmacology and Pharmaceutical Sciences | Protein Targeting And Signal Transduction

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