Discovery Projects - Grant ID: DP0345402

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0345402

Funding Status
Closed

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Funded Activity Summary

An Investigation of the Structure and Conformational Stability of a Membrane Associating Protein and its Petidic Ligands. The genome of the parasite most commonly responsible for fatal malaria will be completed this year. Structural elucidations of proteins identified from these genomic data will expedite the identification and classification of proteins synthesised by the parasite that might be developed as vaccines or as targets for anti-malarial therapeutics. In this work, recent developments in structural biology will be employed to obtain the structure of a vaccine candidate and to identify environmental factors that influence the stability of this structure. A novel approach will be taken to determine the conformation of ligands bound to such proteins, which will provide a basis for the development of therapeutics.

Funded Activity Details

Start Date: 01-01-2003

End Date: 31-12-2004

Funding Scheme: Discovery Projects

Funding Amount: $193,035.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Other Physical Sciences | Membrane Biology | Infectious Agents | Biophysics

ANZSRC Socio-Economic Objective (SEO)

Infectious diseases | Prevention—biologicals (e.g. vaccines) | Treatments (e.g. chemicals, antibiotics) |

Other Keywords

Biophysics | Infectious Agents | Infectious diseases | Membrane Biology | Other Physical Sciences | Prevention—biologicals (e.g. vaccines) | Treatments (e.g. chemicals, antibiotics)

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