Discovery Projects - Grant ID: DP0345376

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0345376

Funding Status
Closed

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Funded Activity Summary

Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression. RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The current study will investigate the structural and biophysical properties of a recently discovered HuR/PCBP/mRNA complex implicated in the regulation of androgen receptor expression. This information has the potential to assist in the development of drugs to reduce AR expression in prostate cancer.

Funded Activity Details

Start Date: 18-03-2003

End Date: 31-12-2006

Funding Scheme: Discovery Projects

Funding Amount: $340,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Macromolecular and Materials Chemistry | Characterisation Of Macromolecules

ANZSRC Socio-Economic Objective (SEO)

Cancer and related disorders | Biological sciences |

Other Keywords

Biological sciences | Cancer and related disorders | Characterisation Of Macromolecules | Macromolecular and Materials Chemistry

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