Discovery Projects - Grant ID: DP0345375

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0345375

Funding Status
Closed

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Funded Activity Summary

Myofibroblast differentiation: from haemopoietic cells to smooth muscle. Until very recently the ability of adult cells with specific differentiated functions to re-differentiate for another function was thought to be extremely limited. However we have shown that cells ultimately derived from the bone marrow can differentiate into fibroblasts, then into myofibroblasts and then into smooth muscle cells. This project will build on these unique findings and determine the molecular mechanisms controlling this process. We hypothesise that the local environment of a cell is critical and will involve a combination of particular extracellular matrix and growth factors as well as mechanical tension and the presence of other cell types.

Funded Activity Details

Start Date: 01-01-2003

End Date: 31-12-2003

Funding Scheme: Discovery Projects

Funding Amount: $60,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall) | Cell Development (Incl. Cell Division And Apoptosis)

ANZSRC Socio-Economic Objective (SEO)

Biological sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Cell Development (Incl. Cell Division And Apoptosis) | Cellular Interactions (Incl. Adhesion, Matrix, Cell Wall) | Protein Targeting And Signal Transduction

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