Discovery Projects - Grant ID: DP0345210

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0345210

Funding Status
Closed

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Funded Activity Summary

A Unique Target in the Purine Biosynthesis of the Pathogen Helicobacter pylori. The uptake systems of purine and analogues of the human pathogen Helicobacter pylori will be characterised because they can be utilised to introduce cytotoxic compounds into the cells. The first step in de novo purine biosynthesis of the bacterium is catalysed by two different enzymes, which are components of other biosynthetic pathways. These unique properties make them excellent potential therapeutic targets. Their individual combined activities in purine biosynthesis will be characterised in situ and in vitro. Isogenic mutants with inactivated genes encoding for these enzymes will be constructed to investigate their role in the survival of the organism.

Funded Activity Details

Start Date: 06-02-2003

End Date: 31-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $125,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Gene Expression | Bacteriology

ANZSRC Socio-Economic Objective (SEO)

Higher education | Treatments (e.g. chemicals, antibiotics) | Biological sciences |

Other Keywords

Bacteriology | Biochemistry and Cell Biology | Biological sciences | Enzymes | Gene Expression | Higher education | Treatments (e.g. chemicals, antibiotics)

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