Discovery Projects - Grant ID: DP0345019

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0345019

Funding Status
Closed

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Funded Activity Summary

Investigating the structure, function and inhibition of the adrenaline-synthesizing enzyme PNMT. We determined the structure of the enzyme PNMT and we plan to use this in the design of PNMT inhibitors to enable us to probe the role of adrenaline and PNMT in the central nervous system. As part of this work, we will further characterise the structure of PNMT by crystallography and mutagenesis. The significance is that designed PNMT inhibitors could eventually be used as leads in the development of compounds with novel pharmacological and therapeutic activity. Furthermore, our analysis of PNMT will determine rules that can be applied to the design of new methyltransferase enzymes with novel functions.

Funded Activity Details

Start Date: 01-01-2003

End Date: 31-12-2006

Funding Scheme: Discovery Projects

Funding Amount: $270,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological And Medical Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Cardiovascular system and diseases | Treatments (e.g. chemicals, antibiotics) | Biological sciences

Other Keywords

Biochemistry And Cell Biology Not Elsewhere Classified | Biochemistry and Cell Biology | Biological And Medical Chemistry | Biological sciences | Cardiovascular system and diseases | Enzymes | Treatments (e.g. chemicals, antibiotics)

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