Discovery Projects - Grant ID: DP0344875

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0344875

Funding Status
Closed

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Funded Activity Summary

Molecular neurobiology of the GABAB receptor: Studies of heteromeric receptor function and signalling. The G protein-coupled receptor (GPCR) for the inhibitory transmitter gamma- aminobutyric acid (GABA) is a unique heterodimer. Molecular analyses will be undertaken to provide insights into its signalling mechanisms and functional regulation. Investigations employing point mutant and chimeric receptors will analyse how ligand binding to the extracellular domain of the GABA-BR1 subunit triggers G protein-coupling to the intracellular portion of the GABA-BR2 subunit. Focus will be on different modes of GPCR signalling, including constitutive activity and roles for membrane and cytosolic regulatory proteins. Targeted studies of GABAB receptor subunits will provide new information on the mechanistic regulation of GPCR signalling.

Funded Activity Details

Start Date: 15-08-2003

End Date: 31-12-2006

Funding Scheme: Discovery Projects

Funding Amount: $240,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System | Basic Pharmacology | Biochemistry and Cell Biology | Protein Targeting And Signal Transduction

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Biological sciences |

Other Keywords

Basic Pharmacology | Biochemistry and Cell Biology | Biological sciences | Central Nervous System | Nervous system and disorders | Protein Targeting And Signal Transduction

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