Discovery Projects - Grant ID: DP0343815

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0343815

Funding Status
Closed

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Funded Activity Summary

A genomic and phenomic investigation of a mitochondrial glutathione transferase. The aim of this study is to understand of the genomics, structure and function of glutathione transferase Kappa (GSTK), a novel GST found in mitochondria. The investigations will achieve several outcomes. (1)an understanding of the organisation of GSTK gene(s) in humans and mice; (2) determination of the role of GSTK in mitochondria, by investigating the phenotype of knockout mice; (3) determination of the crystal structure of human GSTK; (4) An understanding of GSTK's substrate specificity, reaction kinetics and structure/function relationships. Since GSTK is confined to mitochondria, and may not be related to other GSTs, we may also identify novel functions

Funded Activity Details

Start Date: 01-01-2003

End Date: 31-12-2005

Funding Scheme: Discovery Projects

Funding Amount: $240,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Biochemistry and Cell Biology | Genetics Not Elsewhere Classified |

ANZSRC Socio-Economic Objective (SEO)

Human pharmaceutical products | Veterinary pharmaceutical products | Biological sciences

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Enzymes | Genetic Technologies: Transformation, Site-Directed Mutagenesis, Etc. | Genetics Not Elsewhere Classified | Human pharmaceutical products | Veterinary pharmaceutical products

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