Discovery Projects - Grant ID: DP0343521

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0343521

Funding Status
Closed

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Funded Activity Summary

Nanosized peptide nucleic acid - metal complex hybrids as catalysts for the cleavage of phosphate ester bonds in biological molecules. The information from Human Genome Project is being used to generate molecules with a variety of therapeutic and diagnostic applications. The capability to design, synthesise and manipulate functional molecules that mimic biological processes will underpin many emerging applications. In this project, macrocyclic metal complexes that catalyse the cleavage of phosphate ester bonds in biological molecules will be developed. Active complexes will be incorporated into nanosized peptide nucleic acid (PNA) - metal complex hybrids and applied as artificial enzymes in the sequence specific cleavage of RNA and DNA. Novel applications of these ?artificial enzymes? in biotechnology are anticipated.

Funded Activity Details

Start Date: 01-01-2003

End Date: 31-12-2007

Funding Scheme: Discovery Projects

Funding Amount: $280,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Bioinorganic Chemistry | Biological And Medical Chemistry | Inorganic Chemistry | Transition Metal Chemistry |

ANZSRC Socio-Economic Objective (SEO)

Higher education | Biological sciences | Chemical sciences

Other Keywords

Bioinorganic Chemistry | Biological And Medical Chemistry | Biological sciences | Chemical sciences | Higher education | Inorganic Chemistry | Transition Metal Chemistry

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