Discovery Projects - Grant ID: DP0343355

Funding Activity

Website
http://dataportal.arc.gov.au/NCGP/Web/Grant/Grant/DP0343355

Funding Status
Closed

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Funded Activity Summary

Hierarchical Phosphorylation of Tyrosine Hydroxylase is Dependent on the Activation Sequence of Signaling Pathways. Protein phosphorylation is a fundamental process in biology. It controls protein expression and function in all cells. Hierarchical phosphorylation is defined as the phosphorylation of a protein at one site leading to an altered phosphorylation at another site on the same protein and an altered biological outcome. We have discovered that the enzyme tyrosine hydroxylase undergoes a form of hierarchical phosphorylation not previously reported. Here we examine hierarchical phosphorylation in rat and human tyrosine hydroxylase and its functional consequence in intact cells. The approaches and methods developed will also be applicable to investigation of hierarchical phosphorylation in other proteins.

Funded Activity Details

Start Date: 04-02-2003

End Date: 30-06-2006

Funding Scheme: Discovery Projects

Funding Amount: $135,000.00

Funder: Australian Research Council

Research Topics

ANZSRC Field of Research (FoR)

Enzymes | Biochemistry and Cell Biology | Protein Targeting And Signal Transduction | Cell Neurochemistry

ANZSRC Socio-Economic Objective (SEO)

Nervous system and disorders | Biological sciences |

Other Keywords

Biochemistry and Cell Biology | Biological sciences | Cell Neurochemistry | Enzymes | Nervous system and disorders | Protein Targeting And Signal Transduction

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